刘铮博士：教授，博士生导师

教育部长江学者奖励计划特聘教授

1964年出生于新疆石河子市

电话：+86-10-62779876

传真：+86-10-62770304

电子邮件：liuzheng@tsinghua.edu.cn

学术经历与社会兼职

研究领域

代表性著作及专利

实验室简介

英文版

学术经历与社会兼职：

　　分别于1987、1989、1993年在清华大学化学工程系获得化学工程学士、硕士和博士学位。1993年10月至 1994年10月期间在日本东京工业大学生命理工学部进修。1998年在清华大学化工系晋升为教授。目前学术兼职包括中国化工学会生物化工专业委员会副主任和工业生物催化教育部重点实验室主任等。

主要研究方向：

　　主要从事生物化工领域的教学和研究工作，主要内容包括 1）蛋白质构象转换调控及其在蛋白质折叠和分离中的应用，2）纳米酶制剂及其在工业催化中的应用 3）土壤生物修复技术等。发表论文190余篇，其中SCI收录 120余篇，专利授权10项。已培养研究生逾40名，其中全国优秀百篇博士论文1人。2002年获得首届全国高等学校优秀骨干教师奖，2004年入选教育部新世纪优秀人才支持计划，2007年获国务院颁发的政府特殊津贴，2012年入选教育部长江学者特聘教授。

近期代表性著作：

  1. Yifei Zhang, You Yong, Jun Ge and Zheng Liu*, Lectin agglutinated multienzyme catalyst with enhanced substrate affinity and activity, ACS Catal. 2016, 6, 3789-3795
  2. Xian Kong, Diannan Lu,* Jianzhong Wu* and Zheng Liu*, Spreading of a Unilamellar Liposome on Charged Substrates: A Coarse-Grained Molecular Simulation, Langmuir，2016, 32, 3785−3793.
  3. Xiaoling Wu, Jun Ge,* Jingying Zhu, Yifei Zhang, You Yong and Zheng Liu*，A general method for synthesizing enzyme–polymer conjugates in reverse emulsions using Pluronic as a reactive surfactant，Chem. Commun., 2015, 51, 9674-9677.
  4. Fengjiao Lyu, Yifei Zhang, Richard N. Zare, Jun Ge* and Zheng Liu*, One-Pot Synthesis of Protein-Embedded Metal−Organic Frameworks with Enhanced Biological Activities, Nano Letters, 2014, 14: 5761-5765.
  5. Yifei Zhang, Fengjiao Lyu, Jun Ge* and Zheng Liu*, Ink-jet printing an optimal multi-enzyme system, Chem, Commun, 2014, 50: 12919-12922.
  6. Zhixian Li, Yifei Zhang, Yechao Su, Pingkai Ouyang, Jun Ge* and Zheng Liu*, Spatial co-localization of multi-enzymes by inorganic nanocrystal–protein complexes, Chem Commun, 2014, 50: 12465-12468.
  7. Xian Kong, Zhixian Li, Diannan Lu,* Zheng Liu* and Jianzhong Wu*, Multiscale simulation of surfactant–aquaporin complex formation and water permeability, RSC Advances, 2014, 4, 37592–37599.
  8. Yifei Zhang, Qile Chen, Jun Ge* and Zheng Liu*, Controlled display of enzyme activity with a stretchable hydrogel, Chem Commun, 2013, 49:9815-7
  9. Jingying Zhu, YifeiZhang, Diannan Lu, RN Zare, Jun Ge* and Zheng Liu*, Temperature-responsive enzyme-polymer nanoconjugates with enhanced catalytic activities in organic media, Chem Commun, 2013, 49, 6090-6092.
  10. Rui Wang, Yifei Zhang, JinhaiHuang, Diannan Lu, Jun Ge*, Zheng Liu*, Substrate imprinted lipase nanogel for one-step synthesis of chloramphenicol palmitate, Green Chemistry, 2013, 15:1155-1158.
  11. Mengmeng Lin, Diannan Lu, Jingying Zhu, Cheng Yang, Yifei Zhang, and Zheng Liu*, Magnetic enzyme nanogels (MENGs): a universal synthetic route for biocatalysts. Chem Commun, 2012, 48: 3315–3317.
  12. Cheng Yang, Diannan Lu, and Zheng Liu*, How PEGylation Enhances the Stability and Potency of Insulin: A Molecular Dynamics Simulation, Biochemistry, 2011, 50:2585–2593.
  13. Binbin Zhu, Diannan Lu, Jun Ge, Zheng Liu*, Uniform polymer–protein conjugate by aqueous AGET ATRP using protein as a macroinitiator, Acta Biomaterialia, 2011,7:2131–2138.
  14. Zuojun Wu, Hongjun Dong, Liangdong Zou, Diannan Lu and Liu Zheng*, Enriched microbial community in bioaugmentation of petroleum-contaminated soil in the presence of wheat straw. Applied Biochemistry and Biotechnology, 2011, 164:1071-1082.
  15. Hua XF, Liu Zheng* et al., Degradation of hexadecane by Enterobacter cloacae strain TU that secretes an exopolysaccharide as a bioemulsifier, Chemosphere, 2010, 80:951-956.
  16. Jun Ge, Diannan Lu, Jun Wang, and Zheng Liu*, Lipase Nanogel Catalyzed transesterification in Anhydrous Dimethyl Sulfoxide, Biomacromolecules, 2009, 10：1612–1618.
  17. Diannan Lu and Zheng Liu*, Oscillatory Molecular Driving Force for Protein Folding at High concentration: A Molecular Simulation, J. Phys. Chem. B, 2008, 112:2686-2693.
  18. Diannan Lu, and Zheng Liu*, Dynamic Redox Environment-Intensified Disulfide Bond Shuffling for Protein Refolding in Vitro: Molecular Simulation and Experimental Validation, J. Phys. Chem. B , 2008, 112:15127-15133.
  19. Jun Ge, Diannan Lu, Jun Wang, Ming Yan, Yunfeng Lu, and Zheng Liu*, Molecular Fundamentals of Enzyme Nanogels, J. Phys. Chem. B, 2008, 112:14319-14324.
  20. Diannan Lu, Jianzhong Wu and Zheng Liu*, Dynamic Control of Protein Folding Pathway with a Polymer of Tunable Hydrophobicity, J. Phys. Chem. B, 2007，111, 12303-12309.
  21. Ming Yan, Zhixia Liu, Diannan Lu, and Zheng Liu*, Fabrication of single carbonic anhydrase nanogel against denaturation and aggregation at high temperature, Biomacromolecules, 2007, 8, 560-565.
  22. Ming Yan, Jun Ge, Zheng Liu*, Pingkai Ouyang, Encapsulation of Single Enzyme in Nanogel with Enhanced Biocatalytic Activity and Stability, J. Am. Chem. Soc., 2006, 128: 11008-11009.