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GUOQIANG JIANG

 

Ph.D |  Associate Professor

Key Lab of Industrial Biocatalysis of Ministry of Education

Institute of Biochemical Engineering

  
   
   
   
     
 
  • Add: Dept. Chem. Eng., Tsinghua University | One Tsinghua-Yuan Road, Beijing, 100084, China
  • Tel: +8610 62782824
  • Fax: +8610 62782824 /62770304
  • E-mail: jianggq@tsinghua.edu.cn
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    EDUCATION

    		  
  • B.Sc. 2001, Dept of Chemical Engineering, Tsinghua University
  • Ph. D, 2005, Dept of Chemical Engineering, Tsinghua University
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    ACADEMIC EXPERIENCE

    		  
       

     
  • 2005-2007, Postdoctor, Dept of Chemical Engineering, Tsinghua University
  • 2007-2008, Lecturer, Dept of Chemical Engineering, Tsinghua University
  • 2008-     Associate professor, Dept of Chemical Engineering, Tsinghua University
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    RESEARCH FIELDS

    		  
       
      DRUG DELIVERY & BIOMATERIAL　 | more infomation |  
      Current research focused on biodegradable polymeric microparticles for long term controlled drug release, in situ gelling implanted drug delivery system, cell targeting via nanoparticles. The objective of our study on long term controlled microparticle is to explore the relationship and interaction between the drug release and the microstructure as well as the degradation of the microparticles, so as to propose the approaches to modulate drug release rate. Our study on implanted drug delivery system focuses on the development of in situ gelling system based on reverse-thermosensitive polymers. The formulation is solution at room temperature which could be administrated by injection, and becomes semi-solid gel and control the drug release at the body temperature. Our study on cell targeted nanoparticles is concentrated on three aspects: receptor-mediated cell uptake and intracellular transport, nanoparticle penetration in the tumor and nanoparticle material.  
      MULTIPHASE BIOREACTOR　 | more infomation |  
      Current research centered on the development of integrated aerobic/anaerobic biodegradation progress for water treatment and flat photobioreactor for industrial algae culture. We developed the multi-stage air-lift loop reactor (MALR) which shows more advantages than air-lift loop reactor and bubble column. The MALR has been successfully applied to the treatment of industrial wastewater from petrochemical plant, oil recovery and dyeing plant. Based on MALR, we developed flat photobioreactor which shows high light availability and affords high cell concentration culture.
    		  
    		 
       
    		 
       

    TEACHING

    		  
       
      PRINCIPLES OF CHEMICAL ENGINEERING  
     
    Principles of Chemical Engineering is the core course for undergraduate students majoring chemical engineering.
    Content: General principles of separation by equilibrium processes. Staged cascades. Pricinples, unit operations and equipments of seperarion process, including distillation, absorption, extration and drying. Design and calculate the key parameters of the process and equipment. Problem solving methodology involving the equilibrium stage, stage efficiency, staged cascades, number of transfer units (NTU) and height of a transfer unit (HTU).
    Learning Objectives (LO) : Make mass and energy balances around a separation praocess; Understand the phase equilibria and apply it to separation praocess; Apply mass transfer rate equations to separation praocess; Use the concept of equilibrium stage and stage efficiency to determine a separation equipment; Use number of transfer units (NTU) to determine the separation process and equipment; Understand the concept of backmixing; Master the staged cascades methods; Understand and caculate the minimum solvent/absorbent flow rate and minimum reflux ratio; Master the systematic approach preliminarily; Preliminary considerations for technical economy.
    		 
      PHARMACEUTICAL ENGINEERING  
      Contents of the course involved the development of new pharmaceutical products, engineering technology to enlarge and design the pharmaceutical process, unit operations, product packaging and quality control.  
    		 
       
    		 
       

    PUBLICATIONS, PATENTS & AWARDS

    		  
       
      PUBLICATIONS  
     
    1. Guoqiang Jiang* , Shifu Tang, Xuelan Chen, Fuxin Ding. Enhancing the receptor-mediated cell uptake of PLGA nanoparticle for targeted drug delivery by incorporation chitosan onto the particle surface. J Nanopart Res ,2014, 16(6):2453.
    2. Yang Hu, Jishuai Wang, Hong Zhang, Guoqiang Jiang* , Chengyou Kan. Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system. Materials Science and Engineering C ,2014,45: 1–7
    3. Yang Hu, Guanzhi Cheng, Jishuai Wang, Guoqiang Jiang*, Chengyou Kan. Preparation and characterization of cationic pH-sensitive SiO2/polymer core-shell nanoparticles with amino groups in the shell. Colloid Polym Sci. 2014(10), 292: 2611-2620
    4. Guoqiang Jiang*, Jiali Sun, Fuxin Ding. PEG-g-chitosan thermosensitive hydrogel for implant drug delivery: cytotoxicity, in vivo degradation and drug release，Journal of Biomaterials Science, Polymer Edition, 2014, 25(3):241 -256
    5. Wang Y J, Jiang GQ*, Qiu TT, Ding FX. Preparation and evaluation of paclitaxel-loaded nanoparticle incorporated with galactose-carrying polymer for hepatocyte targeted delivery. Drug Development and Industrial Pharmacy, 2012, 38(9):1039-1046
    6. Sun J L, Jiang GQ*, Wang Y J, Ding FX. Thermosensitive Chitosan Hydrogel for Implantable Drug Delivery: Blending PVA to Mitigate Body Response and Promote Bioavailability. Journal of Applied Polymer Science, 2012, 125(3): 2092-2101.
    7. Sun JL, Jiang GQ*, Ding FX, et al. Injectable chitosan-based hydrogel for implantable drug delivery: body response and induced variations of structure and composition. Journal of Biomedical Materials Research Part A , 2010, 95A(4): 1019-1027..
    8. Chen HH, Jiang GQ*, Ding FX. Monolithic osmotic tablet containing solid dispersion of 10-hydroxycamptothecin. Drug Development & Industrial Pharmacy. 2009, 35 (2): 131-137.
    9. Zhao ZY, Jiang GQ*, Ding FX. Anaerobic/Aerobic Biodegradation in an Internal Airlift loop Reactor for Phenol Wastewater Treatment. Korean J. Chem. Eng, 2009,
    10. Li J, Jiang GQ*, Ding FX. Effects of polymer degradation on drug release from PLGA-mPEG microparticles: A dynamic study of microparticle morphological and physicochemical properties. Journal of Applied Polymer Science, 2008,108(4): 2458-2466
    11. Li J, Jiang GQ*, Ding FX. The effect of pH on the polymer degradation and drug release from PLGA-mPEG microparticles. Journal of Applied Polymer Science, 2008,109( 1): 475-482.
    12. Jiang GQ* , Zhu DQ , Zan J, Ding FX. Transdermal drug delivery by electroporation: the effects of surfactants on pathway lifetime and drug transport. Journal of Chinese Chemical Engineering, 2007, 15(3): 397-402.
    		  
         
      PATENTS  
     
    1. Jiang GQ, Tang SF, Yu Y. High-molecular material containing cholic acid and liver-targeting drug delivery nanoparticle modified by same. Patent, CN102351967, 2012-02.
    2. Jiang GQ, Ling Y, Sun JL, Ding FX. In-situ implantation drug delivery system of naltrexone microsphere-hydrogel matrix, Patent , CN101612437; 2011-09.
    3. Jiang GQ, Wang YJ, Tang SF, Ding FX. Airlift-jet multi-stage loop reactor, Patent , CN102166501; 2011-08
    4. Jiang GQ, Chang HG, Jiang SY, He JL, Zhao ZY, Zhang W, Ding FX, Huang Y. Regenerative and integrative hydrogen sulfide liquid phase oxidation absorption method of sulphur separation/desulfuration solution, Patent, CN101870884; 2010-10.
    5. Zhao ZY, Jiang GQ, Jiang ShY, Ding FX.  Bio-degradation process with the integration of hydrolysis acidification, anaerobic degradation and aerobic degradation. Patent, CN101381163, 2010-09
    6. Chen HH, Jiang GQ, Zhu DQ, Jiang ShY, Ding FX. Monolithic osmotic tablet system containing solid dispersion of 10-hydroxycamptothecin and its pereparation. Patent,CN 1872031, 2009-03
    7. Zhao ZY, Jiang GQ，Qiao Y，Ding FX. An anaerobic-aerobic couped method for biotreatment of phenol wastewater, Patent,.CN1850656, 2007-12
    		  
      INDUSTRIAL APPLICATIONS  
     
  • Patent applications: lipid oxidation using air-lift loop reactor to produce the food flavoring. Applied in eight companies. 2008-2012.
  • Industrial project: Reactor for liquid phase hydrocracking of fuel oil (200 kt/a), Shandong Yuhuang chemical (group) Co., Ltd. Shandong, China. Under construction, 2012-2015.
  • Industrial project: Reactor for liquid phase hydrocracking of heavy oil (1.5 Mt/a), Shandong Yuhuang chemical (group) Co., Ltd. Shandong, China. Under design, 2013-2016.
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      HONORS & AWARDS  
     
  • Science and Technology Progress Award (first prize), Ministry of Education, China, 2010 (The forth contributor)
  • Teaching Skill Contests (first prize), Tsinghua University, 2014.
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    SERVICE ACTIVITIES

    		 
       
     
     
  • Editorial Board Member,. Fine Chemicals (in Chinese), 2012-present.
  • Member, Departmental Committee of Fine Chemical Industry of the Chemical Industry and Engineering Society of China, 2012-present.
  • Technical consultant, Hefei Lifang pharmaceutical Co., Ltd, Anhui, China. 2011-present.
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      Copy Right @ Department of Chemical Engineering, Tsinghua University 2015 Update： 2015-04
      Address： One Tsinghua-Yuan Road， Beijing, 100084, China